NONCLINICAL TOXICOLOGY

이 과목은 비임상 독성학의 원리와 응용을 소개하며, 독성학적 평가가 신약 개발, 안전성 평가, 규제 의사결정에서 어떻게 활용되는지를 중점적으로 다룬다. 학생들은 독성학적 시험 방법, 독성 데이터 해석, 그리고 전임상 연구에서의 과학적 고려사항에 대해 학습하게 된다.

By the end of the course, students will be able to: 1. Explain fundamental toxicology concepts (hazard, risk, exposure, dose–response). 2. Describe ADME and toxicokinetic principles relevant to nonclinical studies. 3. Identify common target organs and mechanisms of toxicity. 4. Interpret typical toxicology results and summarize them clearly.

Throughout the course, we will engage in scheduled classroom meetings each week. Lecture slides will be used in class. Students are expected to read assigned sections of the textbook prior to class. Short in-class quizzes/concept checks may be conducted. Selected weeks include small team-based case discussions.

Biochemistry and Organic chemistry required.

This course provides the nonclinical safety foundation needed for upper-level drug development coursework and for understanding how preclinical findings inform clinical dosing decisions, risk management, and regulatory documentation.